Showing symptoms of the disease

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George and Vanessa are recently married and plan to have children. Both were sweat-tested as newborns and tested negative for cystic fibrosis. George's mother and father show no symptoms of cystic fibrosis, but his brother has the disease. Vanessa's mother shows no symptoms of cystic fibrosis and there is no history of the disease on her father's side of the family. However, Vanessa's maternal grandmother (her mother's mother) had cystic fibrosis. Vanessa's maternal grandfather (her mother's father) showed no symptoms of cystic fibrosis, but she has no information about her grandfather's parents or siblings to determine if this side of the family has a history of the disease. Vanessa also has a brother and two sisters, none showing symptoms of the disease.

Constructed pedigree on a plain sheet of paper

Reference no: EM132416848

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