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Antipyretics are often used to lower fever and increase comfort. They decrease the temperature set point by inhibiting the production of prostaglandins. As a result, sweating and vasodilation occur and there is heat loss and a drop in temperature. Antipyretics provide symptomatic relief but do not change the course of the infection. The major benefits of decreasing fever are increasing comfort in the child and decreasing fluid requirements, which helps to prevent dehydration. Children with certain underlying conditions, such as cardiovascular disease or pulmonary disease, also benefit from treating fever because such treatment decreases demands on the body. The use of acetaminophen or ibuprofen to reduce fever in children has been shown to be safe and effective when the appropriate dose is administered at the appropriate interval (Ward, 2019). However, some studies have shown that ibuprofen is superior in reducing fever and lasts longer than acetaminophen (Ward, 2019). See Evidence-Based Practice 37.1. Box 37.3 gives dosing recommendations for both medications.
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