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Allison is a 32-year-old female with the following symptoms: dismal facial expression; droopy eyelids; swollen face and per orbital areas; thin, dry hair; dry, crusty skin; evidence of intellectual impairment; lethargy; a change of personality; bradycardia (59 b/min); blood pressure of 93/72; anemia (hematocrit 28); enlarged heart (upon radiological exam); constipation, and hypothermia. Plasma concentrations of total and free T4 and T3 include:
T4
T3
Total
3.1 µg/dL
0.15 ng/dL
Free
0.5 ng/dL
0.02 ng/dL
Elevated TSH levels were seen from the results of a Free Radioimmunoassay (RIA) of peripheral blood. A TSH stimulation test did not increase the output of thyroid hormones from the thyroid gland.
Describe an appropriate treatment for this patient.
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Evaluating Your Own Risk for Inherited Disease
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