Region of binding between the receptor and the ligand

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Reference no: EM1385252

In studying receptor-ligand interactions, the researcher wanted to narrow down the exact region of binding between the receptor and the ligand. Amino acids 24 - 29 on the receptor were believed to be involved in ligand binding. So the researcher performed mutations in these amino acids and assayed the effect of these mutations by performing binding assays.

Mutations Receptor-Ligand binding

Amino acid 24 No

Amino acid 25 Yes

Amino acid 26 No

Amino acid 27 Yes

Amino acid 28 No

Amino acid 29 Yes

Double mutant Amino acids 24 and 25 Yes

From these experiments.....

What did the researcher learn from mutation in amino acid 24?

What did the researcher learn from the double mutant 24 and 25 ?

Which of the amino acids are involved in receptor-ligand binding? Explain.

Reference no: EM1385252

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