Reduces the risk of heart disease

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Observational studies have suggested that vitamin E reduces the risk of heart disease. Careful experiments, however, showed that vitamin E had no effect. According to a commentary in the Journal of the American Medical Association: "Vitamin E enters the category of therapies that were promising in epidemiologic and observational studies but failed to deliver in adequately powered randomized controlled trials." As in other studies, the "healthy user'' bias must be considered, i.e., the healthy lifestyle behaviors that characterize individuals who care enough about their health to take various supplements are responsible for the better health, but this is minimized with the rigorous trial design. Reread Example 0.1 and the comments following it.

Reference no: EM133516273

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