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Recurrent viral-bacterial and fungal infections

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1. A -year-old patient presents to the clinic with recurrent viral, bacterial, and fungal infections. Analysis of T cells found in her tonsils, which were removed during a previous visit, reveals high numbers of highly activated T-cells, indicated by increased CD3+CD25+ (IL-2 receptor alpha) subset. Which of the following molecule is involved in T-cell activation?

a. CD28 interaction with B7.1 (CD80) and B7.2 (CD86)

b. TIM-3 interaction with Galentin 9 and CEACAM1

c. CTLA-4 interaction with B7.1 (CD80) and B7.2 (CD86)

d. PD-1 interaction with PD-L1 and PD-L1

e. TLR4 recognition of LPS

2. A 12-year-old girl wakes up with an itchy rash the day after helping her grandmother in her flower garden. The girl's mother, a pediatrician, explains the rash is inflammation caused by a signaling cascade activated when interleukin 3 binds its receptor on mast cells in the skin. Which of the following is the transcription factor most likely activated by this receptor-mediated signaling process to induce DNA transcription?

a. IRF

b. JAK

c. MyD88

d. STAT

e. TRIF

Reference no: EM133261436

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