Reference no: EM133261436
1. A -year-old patient presents to the clinic with recurrent viral, bacterial, and fungal infections. Analysis of T cells found in her tonsils, which were removed during a previous visit, reveals high numbers of highly activated T-cells, indicated by increased CD3+CD25+ (IL-2 receptor alpha) subset. Which of the following molecule is involved in T-cell activation?
a. CD28 interaction with B7.1 (CD80) and B7.2 (CD86)
b. TIM-3 interaction with Galentin 9 and CEACAM1
c. CTLA-4 interaction with B7.1 (CD80) and B7.2 (CD86)
d. PD-1 interaction with PD-L1 and PD-L1
e. TLR4 recognition of LPS
2. A 12-year-old girl wakes up with an itchy rash the day after helping her grandmother in her flower garden. The girl's mother, a pediatrician, explains the rash is inflammation caused by a signaling cascade activated when interleukin 3 binds its receptor on mast cells in the skin. Which of the following is the transcription factor most likely activated by this receptor-mediated signaling process to induce DNA transcription?
a. IRF
b. JAK
c. MyD88
d. STAT
e. TRIF