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Question: XPA is a recessive DNA repair disorder that causes skin cancer with even the smallest exposure to sunlight. Heterozygotes (Xx) are carriers, but are not affected. In the U.S., 1/250,000 people have the disease. In Japan, 1 in 22,000 has the disease. What is the frequency of the mutated XPA allele (x) in each population?Question: Phenylthiocarbamide (PTC) tastes bitter to most people. The inability to taste PTC is controlled by a single recessive allele. In the Australian Aboriginal population, 58% can taste PTC, and 42% cannot. Estimate the allele and genotype frequencies of the taster (T) and non-taster (t) allele in this population.
Question: Sickle-cell anemia is caused by receiving two copies of a recessive allele on Chromosome 18Q. The recessive allele has a deletion mutation that causes problems with the hemoglobin complex, and red blood cells curl into a sickle shape as a result. One in 500 African Americans has sickle cell anemia. One in 36,000 Hispanic Americans has the disease.What is the frequency of the sickle cell allele in these two populations?What percentage of these two populations will be carriers of the trait, but not have the disease?
Assume a secondary outcome is recorded in the trial described in Problem 10 reflecting asthma symptom severity measured on a scale of 0 to one hundred, with higher scores indicating more severe symptoms.
Suppose the Sun had a temperature of 17,400 K (three times its present temperature) but was the same size it is now. How much more energy would the Sun emit per second.
Discuss how insertion, deletion, and base substitution of nucleotides can have a significant impact on genes. Find three specific examples of ways in which a very small change in DNA
Case Study: A female patient in ER with suspected toxic shock syndrome
Suppose that you are member of a marine biology team seeking to catalogue the organisms inhabiting a threatened coral reef. The team has found two new seaweeds,
In a donor population, the allele frequencies for the normal and the sickle-cell allele are 0.9 and 0.1 respectively. A group of 55 individuals migrates to population containing 10,000 individuals.
A male Drosphila melangaster is genotypically e^+/e^-, where e (ebony) is an autosomal gene. Of the four gametes produced by a single meiosis.
How are nuclear DNA and mitochondrial DNA transferred.
What genetic basis of erminette pattern is suggested? How will you test your hypothesis. In brief compare the progress of an infectious disease through a well-immunized population with its progress during a poorly immunized population.
In metabolic processes of cell respiration and photosynthesis, prosthetic groups as in heme and iron-sulfur complexes are encountered. What do they do.
So far while surgery was performed on his neck, the surgeon might not find the parathyroid glands at all. Where should the surgeon look next to find out the tumorous parathyroid gland.
Describe how Dendritic cells and T regulatory cells affect immune tolerance. And what woulld happen if there is too much immuno tolerance ?
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