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Question 1
What effect would a drug that either dramatically reduced or enhanced the fidelity of a viral RNA polymerase have on the survival and fitness of a virus in a population? Explain Why? Are there currently examples of such drugs? How do they work?
Question 2
Read the review by Feschotte and Gilbert on Endogenous Retroviruses (ERVs). What are ERVs and why are they important? What impact have they had on viral and human evolution?
Question 3
Read the perspective by Arien et al about HIV evolving to a less virulent form. What are the mechanisms by which HIV may evolve to a less virulent form? What are the arguments for or against attenuation?
Question 4
Read the article by evolutionary biologist Paul Ewald entitled "Guarding against the Most Dangerous Emerging Pathogens: Insights from Evolutionary Biology." Describe his concepts on the evolution of virulence in terms of a virus. Use specific examples of viruses we have studied that demonstrate the concepts he outlines.
Question 5
Watch the recent "Coffee House Presentation" video entitled " Adaptation and Evolution: The Life of an RNA Virus." (The first 20 mins are the presentation and the rest is an excellent Q&A).What is "metagenomics" and how can it be used to detect and prevent emerging viral infections? Why is zoonotic virus transmission the reservoir for emerging diseases? What animals are commonly reservoirs for transmissioto humans? Why?
Verified Expert
It is a very curcial concept to understand how the immune response is mounted against viruses, bacteria, protozoans and helminthes. For an effective immune response, both innate and adaptive immunity should work together.
This Project report elaborates a critical review of important elements attached to Advanced Glycated End Products (AGEs). It is very crucial to understand the process called Millard reaction.
Soil stabilization is the permanent physical and chemical alteration of soils to enhance their physical properties. Stabilization can increase the shear strength of a soil and control the shrink-swell properties.
This assignment has three parts which contains questions related to Microbiology. It contains basic principles of microscopy, staining techniques in microbiology and microbial growth in the food industry.
Lipid metabolites are often seen as key elements in cellular signaling. Is this unique? Please provide several examples of the function of lipids as key elements in signal arrays and list the biologic functions these signals affect?
Please describe how one might search for chemical structure, biologic function relationships, involving small molecular weight lipophylic compounds. Provide one example.
Write a case study which detailing a scenario of a patient being investigated in the Haematology laboratory.
The use of PCR and genetic approaches in biotechnology
Glucose oxidase is an enzyme that can be used for measurements of glucose levels by combining this reaction with an oxygen probe.
What phenotypic ratio would you get if you crossed a white mouse and a heterozygous brown mouse?
Prepare an essay on nosocomial infection.
To increase the awareness of monitoring and recording the blood pressure of patients and practice measuring blood pressure in a safe environment.
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