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Purpose of positive selection during t-cell development

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1. What is the purpose of positive selection during T-cell development? How are positive selection and MHC restriction related?

2. During B-cell activation some activated B-cells undergo differentiation into antibody secreting plasma cells outside of the germinal center and therefore never go through the germinal center responses. Other activated B-cells will return to the follicle forming a germinal center and undergo processes that alter the antibody that will be produced.  

Describe the germinal center responses. Why are these responses important (hint: what is different about the antibody produced)? Why are T cells important in germinal center responses?

Reference no: EM132486923

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