Protein mimics ester bonds instead of amide functionality

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Question- Nature chooses amide bond as its peptide bond. To better understand scientists synthesized artificial protein mimics that were linked by ester bonds instead of amide functionality. They found that these mimcs did not form highly organized structures like those of natural proteins. What would be the reason that would describe lack of folding?

They as well noticed that overtime the aqueous protein mimic solution slowly and spontaneously turned acidic. Explain the observation?

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Reference no: EM13700702

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