Reference no: EM133178509
Cellular and Molecular Basis of Cancer
Aim: To provide you with an understanding of the major cellular and molecular changes that occur during cancer development
Learning Outcome 1: Explain in depth the cellular basis of cancer and relate cellular origin to nomenclature of the major tumour types
Learning Outcome 2: Critically discuss the proposed mechanisms of tumour development, including the stem cell theory and stochastic models of tumour development, and hereditary mechanisms of tumour development.
Learning Outcome 3: Hypothesise how disrupting key cell signalling mediators affects cellular behaviour and tumour development
Learning Outcome 4: Discuss the relative merits of diagnostic and screening tools for the detection of cancers
Coursework Customisation
Using a tumour of your choice*, review the molecular mechanisms resulting in tumour initiation and disease progression. In answering this question, highlight (where relevant) how molecular changes in cancer cells may be used to aid diagnosis, predict prognosis, and determine possible therapeutic interventions
*Possible tumour types:
Hereditary Colon Cancer (either Lynch syndrome, or FAP)
Cutaneous melanoma
Uveal Melanoma
Multiple Myeloma
Osteosarcoma
Lung (Any single sub-type, e.g. ALK+ve, EGFR+ve NSCLC )
Chronic Myeloid Leukaemia
Non-Hodgkin's Lymphoma
Hodgkin's Lymphoma
Glioma
Neuroblastoma
Mesothelioma
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