Previously treated with trastuzumab and pertuzumab

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Question

Your patient is a 67-year-old woman with HER2-positive metastatic breast cancer that was previously treated with trastuzumab, pertuzumab, and trastuzumab emtansine. After an initial response of 8 months, imaging now shows brain metastases. Which of the following treatments would be most appropriate for this patient?

a. Capecitabine plus trastuzumab.

b. Tucatinib plus trastuzumab.

c. Tucatinib plus trastuzumab plus capecitabine.

d. Tucatinib plus trastuzumab plus pertuzumab.

Reference no: EM133727938

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