Prevention of internal acidification

Reference no: EM133700535

Question

We investigated how anaerobic M. tuberculosis copes with challenges to internal pH homeostasis. Our findings indicate that the prevention of internal acidification is critical for long-term survival in the absence of respiration and growth. A failure to maintain cytosolic pH homeostasis appears to be the basis for the death of bacilli in the absence of oxygen. Furthermore, the DosR regulon plays a key role in internal pH homeostasis for anaerobic M. tuberculosis, although the entirety of the mechanisms used by anaerobic bacilli to maintain internal pH homeostasis remains unclear. These findings may provide novel strategies for targeting difficult-to-eradicate hypoxic bacilli that take into consideration pH homeostasis.

Reference no: EM133700535

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