Preventing the exocytosis of ach-containing vesicles

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Botulism toxin (Botox) reduces wrinkles by paralyzing the injected muscle. It does this by preventing the exocytosis of ACh-containing vesicles with the motor neuron axon terminal membrane. Which of the following would you expect in a motor unit affected by Botox? Select the CORRECT statement.

-Action potentials in the motor neuron and muscle fibers would be absent, even after a suprathreshold graded depolarization of the motor neuron.

-At the motor endplate, permeability to Na+ and K+ will remain low after excitation of the motor neuron.

-In the muscle fibers, intracellular free [Ca2+] would be elevated and intracellular [ATP] would be depleted, thus blocking muscle contraction.

-Acetylcholine esterase in the synaptic cleft would be more active than normal, thus reducing the activation of nicotinic ACh receptors.

Why is the correct answer correct and the wrong ones wrong? Having trouble understanding the mechanism.

Reference no: EM132497170

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