Presentation of the native protein

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Antigen-presenting cells have been shown to present lysozyme peptide 46-61 together with the class II IAk molecule. When CD4_ TH cells are incubated with APCs and native lysozyme or the synthetic lysozyme peptide 46-61, TH-cell activation occurs.

a) If chloroquine is added to the incubation mixture, presentation of the native protein is inhibited, but the peptide continues to induce TH-cell activation. Explain why this occurs.

b) If chloroquine addition is delayed for 3 hours, presentation of the native protein is not inhibited. Explain why this occurs.

Reference no: EM132479222

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