Potential interaction between atorvastatin and cyclosporine

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Nurse practitioner calls the pharmacy regarding a potential interaction between atorvastatin and cyclosporine. You consult Hansten and Horn's Top 100 Drug Interactions and discover that cyclosporine is likely to increase systemic exposure to atorvastatin, which is a class 2 interaction using the ORCA system. Which one of the following is best to recommend for managing this interaction? There is no need to avoid this combination; however, monitor the patient closely for signs of myopathy. This combination should always be avoided because the risks of therapy outweigh the benefits. This combination should generally be avoided and used only under special circumstances; a careful risk-benefit analysis and consideration of alternative drug therapies should inform the decision. There is no need to avoid this combination; however, the prescriber can consider alternatives that are less likely to interact, if desired.

Reference no: EM133796087

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