Performing thyroid-stimulating hormone analyses

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Reference no: EM133762010

Question

A physician asks your laboratory to begin performing thyroid-stimulating hormone (TSH) analyses on all specimens that have a free thyroxine (FT4) analysis ordered, a practice that your laboratory currently does not perform. Your laboratory typically performs TSH only on those FT4 specimens that are outside the population-based reference interval. The physician suggests using subject-based reference intervals, claiming that population-based intervals are clinically insensitive. What is the basis of this claim?

Standardized laboratory methods produce more accurate results when examining individual subject values. Subject-based reference values are more easily tracked and applied in settings in which large numbers of specimens are analyzed. Changes in a subject-based reference value might indicate altered biochemical status yet still be within the population-based healthy reference interval. Subject-based reference values more closely resemble the group of reference individuals that were used to establish population-based reference intervals.

Reference no: EM133762010

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