Obese woman is admitted to the emergency department

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Reference no: EM133726625

Case Scenario

A 72 year old obese woman is admitted to the emergency department in an obtunded condition. Her family reports she has a history of high blood pressure and high cholesterol and only takes medicine for these problems. She has no other significant medical history. Her temperature is 37 degrees C, pulse 95/min, respirations 22/min, and blood pressure 90/60 mmg. She appears to be dehydrated and has poor skin turgor. Her serum glucose: 872 mg/dL. Urinalysis: 4+ glucosuria, Ketones- NEGATIVE, protein- NEGATIVE, blood-NEGATIVE. Question 1a: Which of the following factors is most important in the underlying pathophysiology that precipitated this event? • Virus-induced injury to beta cells in islets (of Langerhans) • Severe depletion of alpha cells in islets (of Langerhans) • HLA DR3 and HLA DR4 genotype • Insulin resistance • Autoimmune insulitis

Reference no: EM133726625

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