Reference no: EM133341660

Introduction to Biochemistry and Molecular Biology

Sections

Please be sure that you select your paper topic at your earliest possible convenience. Please read and follow the criteria for choosing a topic in the document posted on Canvas (Guidelines for Choosing a Topic 1, ). When selecting a topic, email me your top three choices and include the enzyme responsible for each disease/disorder.

The following topics have already been selected (You may not select a topic that has already been selected):

Glucose-6-phosphate deficiency, Tay-Sachs disease, Hyperammonemia, Maple Syrup Urine Disease, Gaucher disease, Pompe disease, Fabry Disease, Niemann¬Pick disease, Pyruvate kinase deficiency, Phenylketonuria

Guidelines for choosing the topic for research paper/presentation

• The disease chosen should be caused to a mutation, deletion, or overproduction of a single enzyme.
  • The normal functions of this enzyme should be known
  • Disease that have a multiple causes should not be chosen
• The chosen disease should be well studied so that sufficient information about the causes of the disease documented
  • It is the students responsibility to do some preliminary research in order to determine if there is enough information known about a disease to write a complete paper
• An example of a good topic is sickle cell anemia
  • This disease is caused by a mutation in a single protein - hemoglobin. The functions of normal hemoglobin as well as the mutated hemoglobin are well studied and much is known about the disease.
• An example of a bad topic is Down's syndrome.
  • This disease/syndrome is caused when a third copy of the 21^st chromosome is present. The disease/syndrome is caused by the overproduction of a large number of proteins and has a wide range of symptoms.
  • Other examples of bad topics (the causes are not well known or they are to broad):

• Multiple sclerosis
• Amyotrophic lateral sclerosis (ALS)
• Muscular Dystrophy
• Parkinson's Disease
• Alzheimer's Disease
• Heart Attack and Stroke
• Cancer
• Huntingdon's Disease

• The topic should be unique to this class and cannot be a topic that was used for a paper or presentation in any other class. Students that "recycle" a paper will receive a grade of zero on the paper and presentation. Also, students repeating this class must choose a new topic.
• Each student should email three appropriate topics to the professor in case another student has already chosen his or her first or second choice.