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Question: Scientists were able to show that CML was caused solely by the over expression of the Bcr-cAbl protein kinase and tested 400 small molecules until they found a highly specific kinase inhibitor. This drug was then tested in clinical trials and shown to cause remission in more the 90% of CML patients as long as the drug was taken daily. Why is the specificity important for the success of this drug?
Select one:a. There are fewer side effects if the drug is only inhibiting growth of cells expressing the Bcr-cAbl protein kinase rather than all growing cells (like most chemotherapy).b. If it were a non-specific inhibitor of all protein kinases, it would be highly toxic as there are many essential protein kinases.c. A and B.
When the children of various such two-child families are totaled, what proportion of children in these families will show the phenotype.
Suppose you were given ten ml of milk. You added 0.5 ml of the milk to 9.5 ml of sterile water. After mixing, one ml of the diluted milk was added to 99 ml of sterile water.
Test the given hypothesis of the secondary exposure to cigarette smoking during childhood has importance in developing the lung cancer in person.Describe how efficient is surgical treatment for the Ankylosing Spondylitis.
Describe the most suitable measure of incidence of diabetes in this scenario? Find the risk (ie measure of Incidence identified in part c) of developing type 2 diabetes among females in this community.
The CAP activator protein and the Lac repressor both control the Lac operon. You construct cells that are mutant in the gene coding for the Lac repressor.
Suppose that the lengths of the double-helical regions and the lengths of the single-stranded regions in them vary within relatively tight limits.
A mutaton in the gene W causes a post-pubertal onset of functional defect in Leydig cells. Determine which of the following profiles is associated with a male carrying this mutation in the gene W, at thirty years of age?
A young mother is encouraging her son to try another bite of a disliked food. The child is quietly whining, but when the mother spreads the food around to cool it, the child becomes hysterical. Why did child become so upset? Recognize the cognitive s..
Should society subject pregnant women to dietary restrictions during pregnancy to protect the fetus from the effect of defective genes they carry.
Describe b riefly the role of HOX genes in brain development. If a twenty-five year old woman using Accutane to treat acne discovers that she is pregnant, what concerns do you have for the embryo/fetus?
Show the lines of current flow to unexcited parts of the cable. Elucidate how these local currents cause the action potential to propagate. A common mistake is to confuse the currents that flow throughout the action potential the voltage-clamp curren..
Assume two samples of water are taken just under the surface on a lake, one sample in the early morning, and the other in the late afternoon. Harriet had liposuction several years ago, but has since gained back all the weight lost through the procedu..
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