Name a pair of known inhibitors

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Reference no: EM13147985

A pharmaceutical company has sent you samples of two new metabolic inhibitors to characterize as possible antibiotics. Using a preparation of isolated liver mitochondria incubated in pyruvate, oxygen, ADP and Pi, you find that inhibitor A blocks both electron transport and oxidative phosphorylation. When you add inhibitor B in addition to A, you find that electron transport is restored, but NOT oxidative phosphorylation.

a. How would you classify these inhibitors in terms of mode of action on electron transport and oxidative phosphorylation?

b. Name a pair of known inhibitors that give the same result.

Reference no: EM13147985

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