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A family presents with the same mutation and wants genetic counselling. Your patient, Kimi, is pregnant. She is married to a healthy man without family history of this disease.
This is what Kimi tells you about her family:
"I am the youngest of three siblings. My sister is healthy and married to a healthy man. They have three kids, two boys and a girl. The boys are healthy but the girl is affected. My brother is healthy and is married to a healthy woman. They have one boy and one girl, both healthy. My mother has two brothers and one sister. They are all healthy. My father is an only child. He is healthy, and so were his parents. My maternal grandfather was an only child and was healthy. His wife (my grandmother) was the oldest of seven children (three boys and four girls). One of her brothers was affected, but all others were healthy. Both of my parents are alive but all of my grandparents and their siblings are deceased. It seems that my maternal grandmother's mother was affected but her father was normal. My father is 100% confirmed not to be a carrier. However, I tested negative (no mutation was found) on a mutation screen that is only 80% accurate (i.e. 20% of mutations are missed by the screen)."
Please draw the pedigree of her family.
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This Assignment is designed to evaluate your ability to research, organize, and demonstrate project data and financial information pertaining to the development
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Acquisition of a conjugative plasmid harboring antibiotic resistance genes is one of the easiest ways for bacteria to develop resistance to antibiotics.
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