Membrane potential and action potential

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Case Presentation In Japan pufferfish is served as a seasonal delicacy. Any chefs who want to prepare a meal using this fish has to go through training and licensed through the government. The reason for such precaution is because pufferfish has concentrated neurotoxin in the ovaries and liver, a smaller amount in the intestines and skin, and a trace amount in the muscle. It is considered to be one of the most poisonous vertebrates with no known antidote and had killed unknowing eater (average fatality rate is 6.8%). Even when prepared correctly, a pufferfish meal could cause numbing and tingling sensations. The neurotoxin is called tetrodotoxin (TTX) and its structure is shown below. It's been shown that it blocks voltage gated sodium channel.

Questions

1. Knowing the mechanism of TTX, what do you think it does to membrane potential/action potential?

2. Why would TTX cause numbness?

3. The lethal dose of TTX in mice is about 8mg/kg body weight. What do you think is the likely cause of death?

Reference no: EM133651337

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Membrane potential and action potential : Knowing the mechanism of TTX, what do you think it does to membrane potential/action potential?

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