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A colleague has isolated several mutants that behave normally at low temperature, but at high temperatures exhibit anomalous behavior before or during S phase. You suggest that she characterize the mutant phenotypes at high temperatures in more detail by determining if the pre-replicative complex (pre-RC) forms normally and investigating if the replication origins can fire to initiate DNA synthesis. Once she has finished the suggested experiments, she returns for your help in interpreting the data. Match the phenotype in the left column with a proposed defect in protein function from the right column that may explain each phenotype.A. Cells arrest in G1with normal pre-RCB. Cells arrest in G1with no pre-RCC. Origins fire more than once during a single S phaseD. Cells replicate DNA normally but cannot proceed to M phase1. S cyclins cannot be degraded2. Cdc6 cannot bind ORC3. S cyclins cannot bind Cdks4. Cdc6 cannot be ubiquitinated
What does it mean to be an "multicellular organism"? The cellular slime mold Dictyostelium discoideum exists initially as a collection of separate cells moving over the forest floor.
Discuss chromosomal condition results in an organism being only half as fertile as a wild type individual of the same species?
Assume you have isolated a new recessive tryptophan-requiring mutation in a MAT? yeast strain. You cross this mutant to a MAT? trp1 trp3 strain.
In a mating in 2-individuals with blood type AB, who are both heterozygous for the Bombay phenotype , what percentage of the offspring are expected to appear as having blood type O?
What is the fiber tract that provides for communication between different parts of the CNS called? And what is the one that carries impulses between periphery and CSN called.
Use the cleland representation create the reaction progress of thrombin, a serene protease using a ping pong mechanism on the hydrolysis of the substrate Ala-Arg-Gly-Ala
If a drug company developed a new drug which prevents something like osteoporosis, and has no side effects and has been used for 10+ years
A reaction has been developed to be carried out in the 5 ml total volume. It need a final glycine concentration of 20 µM. If the protocol enables 200µl for glycine addition, state the amount of the concentration would you make up the stock solutio..
A microbiologist found a new restriction endonuclease. When DNA is digested by this enzyme, fragments that average 1,048,500 bp in length are produced.
What SARS viral proteins are made using the frameshifting? Is there only one SARS viral protein made using frameshifting or are there many proteins made using frameshifting?
What issues need to be considered when planning an information systems project to increase data security?
Difference between a hereditary germline cancer, such as those caused by BRCA1 mutations, and cancers that result from two somatic mutations in the same gene in the same cell.
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