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Many diseases which affect the cardiovascular system result from ion channel mutations. One example of this is Timothy syndrome where a mutation (G406R) in the alpha-subunit of L-type Ca2+ channels alters the inactivation properties of the L-type current which can lead to long QT syndrome and potentially fatal arrhythmia
In a computer practical a programme was used to simulate ionic currents in two cell lines, one of which expresses wild-type L-type channels and the other is expressing a mutant L-type channel which was suspected to have similar properties to the G406R mutation that causes Timothy syndrome. The task in the computer practical was to examine and measure some of the properties of this mutant and compare these with the wild-type current.
QUESTION: Suggest further experiments that could be done to assess the physiological effects of the G406R mutation on the heart.
It is a very curcial concept to understand how the immune response is mounted against viruses, bacteria, protozoans and helminthes. For an effective immune response, both innate and adaptive immunity should work together.
This Project report elaborates a critical review of important elements attached to Advanced Glycated End Products (AGEs). It is very crucial to understand the process called Millard reaction.
Soil stabilization is the permanent physical and chemical alteration of soils to enhance their physical properties. Stabilization can increase the shear strength of a soil and control the shrink-swell properties.
This assignment has three parts which contains questions related to Microbiology. It contains basic principles of microscopy, staining techniques in microbiology and microbial growth in the food industry.
Lipid metabolites are often seen as key elements in cellular signaling. Is this unique? Please provide several examples of the function of lipids as key elements in signal arrays and list the biologic functions these signals affect?
Please describe how one might search for chemical structure, biologic function relationships, involving small molecular weight lipophylic compounds. Provide one example.
Write a case study which detailing a scenario of a patient being investigated in the Haematology laboratory.
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What phenotypic ratio would you get if you crossed a white mouse and a heterozygous brown mouse?
Prepare an essay on nosocomial infection.
To increase the awareness of monitoring and recording the blood pressure of patients and practice measuring blood pressure in a safe environment.
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