Low probability of causing dose-related toxicity

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Reference no: EM133747303

Question

Summarize SSRIs generally have a low probability of causing dose-related toxicity; symptoms include: Nausea, vomiting, tremor, myoclonus, irritability (one fatality reported with dose of 6000 mg of fluoxetine; seizure reported in adolescent after ingestion of 1880 mg)

• Rapid onset of seizures with QTc interval prolongation is common with citalopram; citalopram and escitalopram are more likely to cause cardiotox-icity than other SSRIs. Cardiac arrest and torsades de pointes have been reported with citalopram although toxicity has occurred in adults ingesting as little as 100-190 mg

• Altered mental state, QT prolongation, bradyarrhythmias, syncope, and seizures reported following an overdose of citalopram; fatal outcome in 6 patients with citalopram 840-3920 mg (some had also taken other sedative drugs or alcohol); fatalities reported with overdoses of citalopram and moclobemide when co-prescribed

• Case of serotonin syndrome reported after overdose of 8g of sertraline

• Treatment: Symptomatic and supportive

• Citalopram and escitalopram overdose - asymptomatic patients should have continuous ECG monitoring and monitoring of vital signs for 6 h; symptomatic patients until resolution of symptoms.

Reference no: EM133747303

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