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The paper conducts a literature review on the effect of dietary vitamin B on the barrel cortex of the mouse and the stimulating the neural activity of mouse due to lack of vitamin B. However., the paper focuses on the side effects of vitamin B on the barrel cortex of the mouse. It is recognized that Vitamin B assists in maintaining the health of cells and the immune system. But lack of proper amounts of vitamin B on diet can lead to mental health issues among humans and mice also. There are different layers of the barrel cortex of the mouse which are affected by lack of vitamin B on diet. Mice use their whiskers during the process of navigation but vitamin B is essential for stimulating neural activity.