Reference no: EM132802247

1. Why is ammonium chloride given to a patient that has overdosed on methamphetamine?

2. The first step in the drug discovery process is:

a. target validation.

b. lead identification.

c. lead validation.

d. target identification.

3. List four types of chemical drug-receptor interactions.

i. covalent ii. ionic iii. H-bond iv. Hydrophobic

4. What is the mission of drug discovery?

a. To understand how a drug reacts on the body.

b. To determine the level at which the drug is toxic to create a safety threshold for patients using the drug.

c. To improve the functioning of systems in the body by creating drugs that specifically target foreign antibodies.

d. To understand the processes associated with a disease and to identify a drug that can intervene in those processes.

5. For an acid, the (unprotonated / protonated) form is absorbed.

6. For a base, the (unprotonated / protonated) form is absorbed.

7. Describe properties of a drug's structure that lead to selectivity.

8. Which of the following statements is true?

a. Drugs and drug targets generally have similar molecular weights.

b. Drugs are generally smaller than drug targets.

c. Drugs are generally larger than drug targets.

d. There is no general rule regarding the relative size of drugs and their targets.

9. What percentage of drugs are considered natural products or are based upon the structure of a natural product?

a. 81%

b. 61%

c. 41%

d. 21%

e. All drugs are natural products.

10. List four additional subject matter experts necessary for drug development, approval, and manufacturing.

11. List four different sources for new drug structures.

12. What is rational drug design?

13. Describe five of the six approaches used to discover new drugs.

14. At the completion of which clinical trial phase does a company seek permission to market a product in the United States?

a. Phase 1

b. Phase 2

c. Phase 3

d. Phase 4

15. What is the purpose of Phase I clinical trials?

a. To select a lead compound from a lead series.

b. To identify a target population.

c. To establish the safety of administration to humans.

d. To determine if the drug is effective.

e. To compare the drug to similar drugs already approved.

16. Weak acids are excreted faster in ________urine and weak bases are excreted faster in _______urine.

a. Acidic; Alkaline

b. Alkaline; Acidic

c. Acidic; Neutral

d. Alkaline; Neutral