Large sample of null alleles of the gene

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Reference no: EM1390293

1.) A certain Drosophila protein-coding gene has one intron. If a large sample of null alleles (null alleles are mutations that destroy the function of the protein) of this gene are examined, will any of the mutant sites be expected in the
a) exons?
b) introns?
c) promoter?
d) intron-exon boundary?
Please justify your answers. Yes/no is not sufficient
2)A linear fragment of DNA is cleaved with the individual restriction enzymes HindIII and SmaI and then with a combination of two enzymes. The fragments obtained are:
HindIII - 2.5kb and 5 kb
SmaI - 2kb and 5.5kb
HindIII and SmaI - 2.5kb, 3kb and 2kb
Following digestion, the products are run on an electrophoresis gel.
Please draw the uncut figure of the above DNA sequence containing the two restriction sites.
Please draw a representative gel picture (containing the products from the 3 digestion reactions and the uncut fragment) based on the above information.
3.) The effect of base-pair substitution mutations on protein function varies widely form no detectable affect to the complete loss of protein function (null allele). Why do the functional consequences of base-pair substitution vary so widely?

Reference no: EM1390293

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