Ketoconazole for a long period of time

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Ketoconazole is a drug metabolizing enzyme inhibitor when administered systemically. It inhibits CYP3A4. Drug X is an anticonvulsant that is 20% metabolized by CYP 3A4 and 70% metabolized by CYP 2D6. There are no other major elimination pathways for Drug X. What will happen to the AUC, CL, and patient response* to Drug X if a patient homozygous for CYP2D6*4 takes Drug X concurrently with Ketoconazole for a long period of time. Explain

Reference no: EM133228991

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