Iodoacetamide functional group to label the cysteines

Reference no: EM133610766

Question

You performed gel-based activity-based protein profiling (ABPP) to prove that Sotorasib binds to the cysteine of KRASG12C. You planned to use a fluorescent probe bearing an iodoacetamide functional group to label the cysteines. Show the mechanism of this iodoacetamide fluorophore reacting with a cysteine.

Reference no: EM133610766

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