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Maraviroc is a drug designed to block the interaction between HIV attachment proteins and the host cell receptor protein CCR5, thus blocking the initial stages of viral infection. Although Maraviroc shows promise in clinical trials, one major concern is the long term physiological impact of blocking CCR5. Why is this a concern?
a) Long term blocking would cause the CCR5 protein to mutate and it would no longer be functional as a receptor.
b) Like all host cell receptor proteins, CCR5 has a normal role for the cell, and long term blocking by Maraviroc would also block this normal role
c)CCR5 cell receptors would habituate to the continued presence of Maraviroc and the drug would lose its effectiveness.
What is the possibility that the son would have both the Xg antigen and ichthyosis. Why is the man a major candidate for a heart attack.
Explain why does inhibiting the Na/K transport pump in neurons will not have an instant effect on membrane potential. Over time the membrane potential will depolarize.
throughput a heart attack, blood flowing to the heart muscle is interrupted by blockage of a coronary artery. How would you expect the metabolism in the heart to change?
From a bacteria stock you serially dilute 1/100 two times, then serially dilute 1/10 two times. From this last tube you plate 100 ul, which produces 156 colonies the other day.
Utilize your imagination to describe two ways in which disturbance of the sort just described may affect the animals that live on the panels and amount of free space available.
Write a case study which detailing a scenario of a patient being investigated in the Haematology laboratory.
Surface renewal theory predicts that the mass transfer coefficient is directly proportional to the square root of the molecular diffusivity.
A deficiency of carnitine results in muscle cramps, which are increased through exercise or fasting. ATP is required for muscle contraction.
Examine of the bases of a sample of nucleic acid yielded these percentages: A= 20%, G= 30%, C= 20%, T= 30 percent. Explain why is the sample single stranded DNA.
Explain why is agar typically used as a solidifying agent in microbiological media instead of gelatin? What could happen if gelatin was used?
What would happen to urine output of a rabbit if cells of tunica media of all glomerular afferent arterioles were totally inactivated?
The "Primordial soup" includes the mixture of elements and gases which are thought to have started life on the Earth. Explain one thing in biosphere you would like to modify. Why do you feel this way? What do you think can be accomplished to implem..
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