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Xenobiotic shown below is a pesticide commonly used in developing countries, but is largely banned in the United States because of its potent neurotoxic effects. To mediate these neurotoxic effects, the pesticide must be able to cross the blood brain barrier. Inspection of the chemical/physiochemical properties of the pesticide suggest it would not readily diffuse across membranes and be absorbed through the skin or GI tract, much less cross the blood brain barrier. To understand how the pesticide can distribute to the brain, the following experiments were performed. Mice were fed the pesticide and then sacrificed 24 hr later. Their brain tissue is stained with an antibody that binds the toxin and gives a green color. The results of the experiment are shown in the immunostain below. Panel (a) is no pesticide administered and Panel (b) is with the pesticide. Panel [c] is the same dose of pesticide as (b) with the addition of a large concentration of the amino acid arginine.
Explain why inspection of the structure of the pesticide would suggest it would not accumulate in the brain. What does the inhibition of pesticide accumulation in the brain by the amino acid arginine suggest about the mechanism of transport of the pesticide (limit 5-6 sentences)?
Describe the functional relationship between the respiratory system and the lymphatic system. Several of the ten leading causes of death are identified as being related to nutrition, including cardiovascular disease, cancers, and diabetes.
In a Neurospora cross ab x ++, gene a is on chromosome 1 and gene b is on chromosome 6. It is known that the two loci are so closely linked to their centromeres that there is never any crossing over in either region. What proportions of the linear te..
Assume many of the atoms of nitrogen in a double-stranded molecule of DNA, of isotope N-14, were replaced with the isotope N-15
Discuss the theory of Naturalist intelligences developed by Howard Gardner, discuss how it can have an impact on your personal success,400 words!
What are e any 2 physical variables responsible for North Atlantic and north pacificgyres (keep in mind these gyres give rise to all of theimportant oceanic an along shore currents).
Many genes have been cloned and sequenced. The precise amino acid sequence of a polypeptide can be determined from the DNA sequence and the molecular weight can be calculated.
What is attenuation? How does this work in the trpoperon? Why is attenuation important?
Explain the role of transposable elements in eukaryotes and Explain the possible role of telomerase in cellular aging and in cancer formation
A student performed a BioRad miniprep of plasmid DNA that resulted in 100ul(microliter) of DNA solution. To determine the concentration of this solution, 20ul of the DNA solution was placed in 480ul of water and the absorbance of the diluted sampl..
How are the hypothalamus and anterior pituitary central to endocrine regulation?
how efficient is fermentaion? how efficient is cellular respiration ? Eggiciency is calculated as the amount of useful energy (as ATP) gained during the process divided by the total amount of energy available in glucose. Use 686 kcal as the total ..
Which person would tend to have a higher proportion of slow-twitch than fast-twitch muscles: a weight lifter, a sprinter, or a long distance runner?
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