Inhibition of cell wall synthesis

Reference no: EM133692216

Question

Explain the mechanisms of actions and provide example drugs of the following.

a. Inhibition of cell wall synthesis: Blocks the formation of peptide cross links in order to weaken the cell wall and end up causing the cell to lyse.

i. lactams such as penicillin and methicillin: penicillian with gram positive cocci and some gram-negative bacteria. Methicillin treats infections from penicillin resistant bacteria.

ii. Cephalosporins

b. Inhibition of protein synthesis: bind to subunits to inhibit ribosome assembly.

i. Aminoglycosides: changes the shape of the subunits so its unable to read the mRNA and incorrect amino acids leading to wrong protein ii. Tetracyclines: block the docking side of the transfer RNA, preventing amino acids from being added.

c. Inhibition of folic acid synthesis

i. Sulfonamides: Blocks pathways and inhibits metabolism

d. Disruption of cell membranes

i. Polymyxins: attacks the cytoplasmic membrane making it interfere with its integrity and cause cell to lyse. Extremely toxic only used topically.

e. Disruption of DNA and RNA synthesis

i. Fluoroquinolones: Block DNA gyrase, an enzyme in DNA replication, to inhibit bacterial replication.

ii. Rifamycin: bind more readily to RNA polymerase in prokaryotes than eukaryotes and can be used to block transcription

7. Explain how drug resistance develops

Reference no: EM133692216

Questions Cloud

Real-time interactive teleneurology service : What are the legal risks and liability issues of a real-time interactive teleneurology service to determine the administration of thrombolytics to suspected

Design plan of action using evidence informed sources : Design a plan of action using evidence informed sources (35%) A well-considered and constructed plan of action is presented

Current policy transformed current practice of nurses : How has current policy transformed the current practice of nurses, physicians, and other healthcare professionals?

Discuss the pathophysiology of gastric ulcer : Discuss the pathophysiology of gastric ulcer and the contributing factors for the disease condition in Chandler's case.

Inhibition of cell wall synthesis : Inhibition of cell wall synthesis: Blocks the formation of peptide cross links in order to weaken the cell wall and end up causing the cell to lyse.

Determine the key audience and stakeholders : Determine the key audience and stakeholders. Establish evidence-based measurable objectives for the audience.

Advance-innovation used in healthcare system : Evaluate your present professional practice. Select one surfacing technological tool/advance/innovation used in a healthcare system.

Impact on our health care system : Assignment Using what you have learned in the course, discuss a current trend in health status and its impact on our health care system.

What is the scenario in your coding clinic : What was the Year, quarter and topic you selected? What is the scenario in your coding clinic? What was the answer provided in the expert advice?

User Account

All Pages