Increased numbers of tissue breaking procedures

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Increased numbers of tissue breaking procedures during NICU have been associated with poorer cognitive, motor, and behavioural neurodevelopmental outcomes in infancy [6]. In extreme preterm birth cohorts, 25-30% had required neonatal surgery [7,11], and this was associated with increased rates of major neurosensory disability in childhood [11] and lower cognitive scores that persisted into late adolescence [7,8]. Effects could not be related to specific surgical procedures (most commonly inguinal hernia repair, patent ductus arteriosus ligation, bowel surgery, surgery for hydrocephalus), although it was noted that the different subgroups were relatively small.

Reference no: EM133803893

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