Impact of antibodies on neuromuscular junction signaling

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How would antibodies against nACh receptors affect neuromuscular junction signaling as it relates to excitation-contraction coupling? Discuss in detail the impact of these antibodies on neuromuscular junction signaling. Include in your answer a discussion of how motor end plate potentials and sarcolemma action potential generation are impacted as well as calcium signaling to/from the sarcoplasmic reticulum. Relate everything to the impact these mechanisms would have on Sandy's muscle's ability to contract and generate force.

 

 

Reference no: EM133278903

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