Identify a clone of mutant cells

Reference no: EM133661969

Assignment:

a. When you treat cells with the XF1 ligand, you typically observe a strong drop in PI(4,5)P2 levels, a strong increase in PI(3,4,5)P3 levels. However, you also observe a very modest increase in cAMP. What is a likely explanation for these effects?

b. You now identify a clone of mutant cells that, when stimulated with XF1, have the same strong drop in PI(4,5)P2 and increase in PI(3,4,5)P3, but also show a strong increase in cAMP levels. You map the mutation to the 'switch 1' region of XGP. What is a likely effect of this mutation?

Reference no: EM133661969

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