Hypothalamic-pituitary-gonadal

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The hypothalamic-pituitary-gonadal (HPG) axis works similar to the thyroid hormone axis and is diagrammed below. Notice that the feedback loops change throughout the estrous cycle (the estrous cycle is a set of recurring physiological changes that are induced by reproductive hormones in most mammalians with ovaries)

-If there is a molecule that blocks estradiol receptors on the anterior pituitary to a patient in their follicular phase, After four hours (this patient is still in follicular phase), how will level of GnRH, FSH/LH and Estradiol change comparing to a patient who was not given estradiol blocker?

-If there is a molecule that blocks estradiol receptors on the anterior pituitary to a different patient in their midcycle phase, After four hours (this patient is still in midcycle phase), how will level of GnRH, FSH/LH and Estradiol change comparing to a patient who was not given estradiol blocker? 

-If there is a molecule that blocks the GnRH receptor to a third patient in their luteal phase. A healthy person would respond to this injection by producing higher levels of GnRH. Your patient produces normal levels of GnRH. Unfortunately, you forgot to take your patient's hormone levels before you introduced this molecule. what are the changes in TWO different proteins that could (separately) lead to the normal GnRH levels in your patient after you introduce the molecule? For each protein, how the change would lead to the normal GnRH levels in your patient after the addition of this molecule? 

Reference no: EM132526263

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