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Researchers working on HIV (human immunodeficiency virus) and SIV (simian immunodeficiency virus) vaccines found that an antibody to a particular epitope of SIV (that was identical with the corresponding HIV-2 epitope) had a potent virus-neutralizing activity against numerous SIV and HIV-2 (but not HIV-1) isolates. This epitope was determined to be an octapeptide (= consisting of 8 amino acids linked in a polypeptide chain). This octapeptide was synthesized and used to immunize 20 individual rhesus macaques (Macaca mullata), but no protection against SIV in vivo was observed in the immunized animals. What could be the best explanation(s) for this peptide vaccine failure? Assess the following hypothetical explanations (1- 10) as either factually correct (= "true") or incorrect (= "false"):1. The peptide could not be processed by dendritic cells.2. The peptide could not be processed by B cells.3. The peptide could not be processed by activated macrophages.4. The vaccinations did not work, because the peptide was too long.5. The vaccinations did not work, because the peptide was too short.6. The vaccinations did not work, because the peptide was insufficiently complex.7. The vaccinations did not work, because the induced cytokine response was too weak.8. The vaccinations did not work, because T-cell epitopes were absent.9. The vaccinations did not work, because the octapeptide failed to activate NK cells.10. The vaccinations did not induce adequate amounts of interferon-? to activate professional antigen-presenting cells.
Suppose that you perform the following monohybrid cross in dogs: Aa X Aa, in which the dominant A allele produces black coat color and the recessive a allele produces a white coat color.
Receptor ligand interactions, the researcher wanted to narrow down exact region of binding between the receptor and the ligand.
Assume you make buffer solution by adding four gram sodium bicarbonate to 270 milliliters of water then titrate this solution to 30 ml of 0.1 molar HCl and find the equilibrium equation for this base/acid pair.
Idea of scientific integrative medicine and relates them to the physiology of catecholamine systems and to pathophysiology of catecholamine related disorders.
A new enzyme you are studying has a Km of 7.0mM and a kcat of 126 per second. What will be the initial rate of reaction in units mM/min when 9.3 nanometer enzyme is reacted with 2.7 mM substrate. Report your answer in units if mM/min to nearest 1m..
The binomial name of an organism consists of the names of which two classification categories. Smoking, air pollution and altitude all affect the rate of respiration. Explain the effects of each of these on respiration and Why.
On chromosome three of corn there is a dominant gene (A1), which together with the dominant gene (A2) on chromosome 9, produces colored aleurone.
Discuss how does the altered primary structure of hemoglobin from sickle cell patients affect its tertiary structure?
Imagine looking during a microscope at a squashed onion root tip. The chromosomes of many of cells are plainly visible. In some cells, replicated chromosomes are aligned along center (equator) of the cell. These particular cells are in which stage of..
The "Primordial soup" includes the mixture of elements and gases which are thought to have started life on the Earth. Describe Miller and Urey's experiment.
Approximately what percentage of the energy of glucose is transferred to storage in ATP as the result of the complete oxidation of glucose to CO and water in cellular respiration.
Carotenoids are frequently found in foods that are considered to have antioxidant properties in human nutrition. What related function do they have in plants.
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