Human blindness would result in free-running clock

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Which causes of human blindness would result in a free-running clock? Assume the human and mouse systems operate the same.

a. Vitamin A deficiency resulting in a complete loss of retinal cofactor for Opsin protein

b. Dominant Melanopsin (Opn4) mutation resulting in constitutive 2nd messenger signaling

c. PDE6B mutation causing degeneration of rods and cones

d. Stroke resulting in a complete destruction of the lateral geniculate thalamus

e. Blindness via adult-onset autoimmune destruction of all bipolar cells

 

Reference no: EM133292994

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