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You have been asked to investigate a specific human disorder, Crystal disease. The disorder is caused by a recessive mutation in the human gene A1. The disorder results in impaired vision, cognitive defects and early death. A short lived mutation has been isolated in butterflies which also causes neural degeneration and has been shows to affect the butterfly homologue of A1. A mouse homologue gene has been identified but is not cloned ( no one has isolated the gene sequence) and no mutations in the gene are known to exist. You are not a MD therefore cannot conduct human research. Two proposals has been submitted to you for evaluation. A. The first recommends using butterlies to conduct a suppressor screen for the phenotype associated with the mutation of A1. B. The second recommends generating a mouse model for Crystal disease. Explain how both would be conducted and provide a rationale for choosing one or the other approach. For A describe how you would perform the mutangenesis, what criteria you would use to identify suppressors, how would you clone and sequence the suppressor gene. For B explain how you would obtain the mouse sequence, how you would generate the knockout construct, how you would make the knock out mouse and how you would evaluate the reliability of the mouse model.
1. What were the problems in the Pacific halibut fishery, and how were they resolved? 2. Under what conditions will a natural area receive protection? 3. Compare the concept of ecosystem capital with that of natural resources.
To integrate an F plasmid's genes into a host chromosome, there must be DNA recombination at homologous regions on the two circular strands. What is the minimum number of such crossover events needed for integration?
Lithops, also called Stoneplants, are a type of plant that resembles little stones. These plants have the ability to blend in with their surrounding, which affords them protection from predators. If you were in an area containing Lithops.
What is the function of the retina? What is the function of the choroid layer?
Why would someone use a split ratio as opposed to making a cell count? What is the major drawback to performing a split ratio?
Assume A broth contains bacterial cells at a concentration on 10^5 cells per milliliter. You dilute this broth through removing 1ml and adding it to 9ml.
Describe how the hypothalamus controls secretion from the pituitary gland. Be specific regarding circulation and communication between the two regions.
Explain how you would prepare 200 ML of a 0.25 Msoluation of NaOH from a 3 M stock solution?
People say the dose makes the poison, actually, the dose determines the concentration, and the local concentration determines the toxicity the poison.
Think about the sequence 3'-T-C-T-C-T-A-C-G-T-5' and calculate the total number of covalent bonds joining the nucleotides in each strand?
Which of the following do anaerobic methanogens produce?
In your own words, what is homeostasis? Explain completely. What happens when homeostasis is not maintained?
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