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Problem
Samuel Wilson is a former smoker with a 30-pack-year smoking history. He was recently diagnosed with stage IIA non-small cell lung cancer (NSCLC) with metastasis to the lymph nodes. Subsequent tissue biopsy indicated that the tumour was an adenocarcinoma with high PD-L1 expression in the tumour cells.
Samuel's oncologist recommended treatment with a PD-1 inhibitor as part of his therapy for his NSCLC. He started receiving pembrolizumab every three weeks. After the initiation of treatment, his response and overall well-being were closely monitored.
Question A. Describe the characteristics of the tumour size, lymph node involvement and metastasis,Question B. How does a PD-1 inhibitor work in the treatment of lung cancer?Question C. How would you monitor John's response to pembrolizumab?
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