How would the 2-flouro substitution prevent cleavage

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Reference no: EM13110602

Many groups are using modified RNA with 2'-deoxy-2'-fluoro substitutions for riboses (i.e. a 2'-fluorine instead of a 2'-OH) to prevent RNA cleavage by ribonucleases.

How would the 2'-flouro substitution prevent cleavage of the phosphodiester bond by ribonucleases?

Reference no: EM13110602

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