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How will the combination of warfarin and tmp-smx affect

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Question: LR has been on warfarin for 2 months. He has been anticoagulated with warfarin 6 mg/day with good control. He was seen in the ED for symptoms of a UTI for which he was prescribed trimethoprim-sulfamethoxazole (TMP-SMX) BID x 10 days. How will the combination of warfarin and TMP-SMX affect LR's anticoagulation? Should his warfarin be adjusted or another drug substituted for TMP-SMX?

Reference no: EM133584097

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