How might a point mutation create a hyperactive

Assignment Help Biology

Reference no: EM13156727

The src gene product is a nonreceptor protein kinase called pp60src. This protein is a tyrosine protein kinase that phosphorylates target proteins at specific tyrosine residues. This tyrosine protein kinase is an integral member of a signal transduction pathway leading to the transition from G2 to M phase. The pp60src protein is phosphorylated by an upstream kinase. The phosphorylation changes the conformation of the protein such that its kinase domain is exposed and is able to then phosphorylate downstream target proteins.

How might a point mutation create a hyperactive form of pp60src (the src gene is a proto-oncogene)?

Reference no: EM13156727

Questions Cloud

Should this machine be purchased : The company depreciates its assets on a straight-line basis and has a marginal tax rate of 40 percent. The firm's cost of capital is 14 percent. Based on the internal rate of return criterion, should this machine be purchased?

Total purchase price for asset : In addition, the partnership purchased all of the assets of Granny Newcombs, Inc. Of the total purchase price for these assets, $60,000 was allocated to the trade name and logo.

What can one conclude about the two proteins : a scientist isolates two specific mRNAs. one codes for the enzyme fowlase, an enzyme that is involved in digestion in chickadees; the other codes for the quail enzyme quailase that is involved in cellular carb metabolism.

Calculate the present worth of the incremental system : d. Perform an annual equivalence analysis for the two options, and state which is the better option and why. Calculate the present worth of the incremental system (1 - 2), and state which option is better and why.

How might a point mutation create a hyperactive : The src gene product is a nonreceptor protein kinase called pp60src. This protein is a tyrosine protein kinase that phosphorylates target proteins at specific tyrosine residues.

What tax issues should regina consider : Regina accepted a new job in Dallas in April 2008. Unable to rent her home, she rented it in November 2008, at which its fair market value was $240,000. In June 2010, she sold the home for $230,000. What tax issues should Regina consider?

Compute ml of naoh needed to reach the equivalence point : Calculate: A) mL of NaOH needed to reach the equivalence point B) pH of the solution before the addition of any NaOH C) pH of the solution after the addition of 15.0 mL of NaOH

Find the p-value and interpret it using excel : State the decision rule and sketch it. (c) Find the test statistic. (d) Make a decision. (e) Use Excel to find the p-value and interpret it.

What is the effective interest rate of an investment : What is the effective interest rate of an investment if the nominal annual interest rate is 4.67% and it is compounded semi-annually? Express your answer as a percent to two decimal places.

User Account

All Pages