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Your friend is studying mouse fur color and has isolated the GPCR responsible for determining its color, as well as the extracellular signal that activates the receptor. She finds that, on addition of the signal to pigment cells (cells that produce the pigment determining fur color), cAMP levels rise in the cell. She starts a biotech company, and the company isolates more components of the signaling pathway responsible for fur color. Using transgenic mouse technology, the company genetically engineers mice that are defective in various proteins involved in determining fur color. The company obtains the following results. Normal mice have beige (very light brown) fur color. Mice lacking the extracellular signal have white fur. Mice lacking the GPCR have white fur. Mice lacking cAMP phosphodiesterase have dark brown fur. Your friend has also made mice that are defective in the ? subunit of the G protein in this signaling pathway. The defective ? subunit works normally except that, once it binds GTP, it cannot hydrolyze GTP to GDP. What color do you predict that the fur of these mice will be? Why? PLEASE EXPLAIN
Describe a signaling pathway deregulated in cancer that involves pRb and p53 as players. Have any advancements been made in the understanding of these pathways since the provided review was written?
Using a five step protocol, you have purified an enzyme to the point where the specific activity remains constant when you perform any additional purification steps.
To stain your cells, you need to apply 0.75mL of staining solution to the fixed cells. How much is this in uL.
The big majority of the frogs in this population are green. A few individual frogs carry a mutation that prevents the production of the green pigment.
Enter in the box the correct answer for each question regarding the output at various points during the catabolism of glucose. Type a number, do not spell the word.
A person eating a contaminated shellfish can lose the ability to breathe within minutes, but may be rescued if placed on a ventillator for a period of days.
Most people with Broca's aphasia suffer from partial paralysis on the right side of body. Most people with Wernicke's aphasia do not. Why.
Determine the possible DNA sequences that produced the four amino acids in the molecules
Haemophilus influenza requires hemin to synthesize cytochromes and NAD from other cells. For what does it use these two growth factors? What disease(s) does H. influenza cause?
Consider a transmembrane protein complex that forms a hydrophilic pore across the plasma membrane of a eukaryotic cell. The pore is made of five similar protein subunits, each of which contributes a membrane-spanning alpha-helix to form the pore.
A species has a diploid number of 2n. Meiosis I fails during spermatogenesis, cytoplasm does not divide and only one daughter cell is manufactured. The resulting sperm fertilizes a normal ovum.
While you measure the genotype frequencies of the population you get the following data. What will the frequency of Aa be in the next generation.
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