How do these link to the brain areas that are affected

Reference no: EM133563840

a) Using appropriate terminology, describe what is meant by 'randomised' and 'controlled' in the context of this particular trial. Note that you do not need to understand or refer to cluster randomisation in your answer.

b) Focusing on one of the primary outcome measures, describe the following:

the inclusion criteria, described in general terms (i.e. not simply copied from the article)
number of participants in each condition at the start of the trial
the independent variable
the dependent variable
the two endpoints of the trial
c) Looking at Table 2 in the article, describe the changes seen in the MoCA scale between baseline and postintervention for the two groups of participants. You should give the values for the amount of change for each group in your answer. What does this mean in terms of changes in symptoms for the two groups? Comment on whether the changes measured were statistically significantly different between time points and between the two groups of participants, and how you know this.

d) The data from the trial were analysed using the 'intention to treat' principle. Using your knowledge from Topic 8, explain what this type of analysis means and how it has been applied in this particular trial. Using information from Figure 1 in the article, explain how the data analysis in the trial would have differed if the researchers had used the 'per protocol' type of analysis.

e) From the discussion in the article, describe the main difference between the results of this study and the results of previous studies on the effectiveness of cognitive therapy in adults with MCI. How do the results of the study in the article extend our understanding of the effectiveness of cognitive therapies in adults with MCI?

f) The authors of the article discuss several types of brain functioning that are improved with the CrExp intervention. How do these link to the brain areas that are affected in Alzheimer's disease? In your answer, you should use your knowledge from SK298 to describe which brain areas are affected in Alzheimer's disease and their functions.

Reference no: EM133563840

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