How could dr. rochester test his hypothesis

Reference no: EM133349944

Question: Dr. Rochester is running a clinical trial in which patients with treatment-resistant depression (TRD) are receiving deep brain stimulation (DBS) in their lateral habenula (LHb). He hypothesizes that TRD patients have a chronically overactive LHb, and that after 4 weeks of LHb DBS treatment, LHb activity will decrease and the patients will show improvement in their depression symptoms.

a. How could Dr. Rochester test his hypothesis that his TRD patients have an overactive LHb relative to people without depression? Describe a method that Dr. Rochester could use to answer this question, and what his experimental and control groups should be. What result from this experiment would support Dr. Rochester's hypothesis?

b. How could Dr. Rochester test his hypothesis that TRD patients receiving LHb DBS treatment have decreased LHb activity after four weeks of treatment? Separately, how could he quantitatively measure their symptoms of depression to determine if their depression has improved? Briefly describe how Dr. Rochester could experimentally address each of these hypotheses.

Reference no: EM133349944

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