How can diabetes cause endothelial dysfunction

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Like many Fortune 500 companies throughout the world, IBM in India finds that picking the best prospects for job postings isn't always easy. By using advanced analytics, however, it aims to connect the strategic plan, staffing needs, and the hiring process using a simple tool. The project was originally developed to assign people to projects internally at IBM, but IBM found this tool able to not only extract essential details like the number of years of experience but also make qualitative judgments, such as how good the person actually is for the job. 9 This makes the software unique, as most résumé-scanning software programs can only search for specific keywords and are not able to assess the job fit or tie the criteria directly to the overall strategic plan. The project uses IBM India's spoken web technology, in which the prospective employee answers a few questions, creating the equivalent of voice résumé. Then using these voice résumés, the hiring manager can easily search for those prospects who meet the needs of the organization and the objectives of the strategic plan. Some of the challenges noted with this software include the recognition of language and dialect issues. However, the IBM human resources solution is still one of the most sophisticated of such tools to be developed. "Services is very people-intensive. Today, there is talk of a war for talent, but attracting the right kind of people is a challenge, yet unemployment is very high. Our solution applies sophisticated analytics to workforce management," says Manish Gupta, director at IBM Research-India. 10 It is likely that this is only the beginning of the types of technology that allow HR professionals to tie their HR plans directly to a strategic plan with the touch of a few buttons.

Question 1: Is the use of amlodipine or furosemide recommended to normalize blood pressure in a case of hypertensive heart failure? If so, which is most effective?

Question 2: How can diabetes cause endothelial dysfunction? What are the roles of ACE inhibitors in the kinin-kallikrein system? What are the mechanisms by which a decrease in the level of nitric oxide causes endothelial dysfunction?

Question 3: Can sublingual nifedipine be given to a patient with malignant hypertension/accelerated hypertension? It seems to be a controversial issue with some favouring it and some against it.

Question 4: Is the diagnosis of malignant hypertension based only on the basis of the retinopathy (even in the presence of a normotensive state)? Labetalol, parenterally, is suggested as a treatment for malignant hypertension. What other more readily available preparations (besides sodium nitroprusside) are recommended in addition to this drug? Parental labetalol is not available in Pakistan!

Question 5: Patients at medium risk of DVT and pulmonary embolism are usually given specific prophylaxis with low-dose heparin at a dose of 5000 units subcutaneously every 8-12 hours until the patient is ambulatory. Is the first dose given immediately after, say, extensive varicose vein surgery of small and great saphenous veins?

Question 6: 'Anticoagulants are not necessary, as embolism does not occur from superficial thrombophlebitis' (K&C 7e, p. 809). Why?

Question 7: Can we use enoxaparin for deep vein thrombosis (DVT) prophylaxis in the immediate postoperative period and in a case of cerebral haemorrhage? Wouldn't it increase the risk of haemorrhage in either case?

Question 8: Can external jugular vein thrombosis cause tingling numbness over the earlobe and adjoining part of the lower face?

Question 9: For how long does a patient have to stay in bed to be labelled as bedridden and to merit low-molecular-weight heparin (LMWH) as prophylaxis for deep vein thrombosis?

Question 10: Is an inferior vena cava filter an alternative treatment for a patient with a history of recurrent deep vein thrombosis on lifelong anticoagulation with warfarin?

Reference no: EM132958542

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