How are penetrance values obtained for presumed genetic

Reference no: EM133457277

Question: Genetic linkage studies can be either based on a model of inheritance or parameter-free. For the former, one needs to know the mode of inheritance and the penetrance (age-risk function). How are penetrance values obtained for presumed genetic susceptible?

Twelve families are selected for a genetic linkage study because of a high prevalence of disease. A genome screen is performed, using anonymous DNA markers on all autosomes. Significant evidence is observed for linkage to a marker on chromosome 2 (D2S123) in four families. The LOD score for the remaining families at this locus is significantly negative. How do you interpret this finding?

Reference no: EM133457277

Questions Cloud

What were foundations of his political philosophy : Discuss the role that Qin Shihuangdi played in the unification of China. What were the foundations of his political philosophy?

Who do you think madisons specific audience was : Discussed in lecture regarding this essay. According to the discussion in the lecture, who do you think Madison's specific audience was?

Describe the three types of market share : Describe the three types of market share. What are the advantages of monitoring market share? Discuss the concept of a marketing audit, the main components

What are cultural differences associated to the jamaican : What are the cultural differences associated to the jamaican use of ganja and mexicos ritual marihuana describe two types of drug networks identified by jones.

How are penetrance values obtained for presumed genetic : How are penetrance values obtained for presumed genetic susceptible? Twelve families are selected for a genetic linkage study because of a high prevalence

List three occasions when it might be necessary to provide : List three occasions when it might be necessary to provide referrals for a client and list 10 service options that might be provided by other organisations

What about the oklahoma laws : What about the Oklahoma laws and Dr. Dougherty's stature in the community allowed him to continue to act with immunity for so long?

How might the spread of hellenism and the mystery religions : How might the spread of Hellenism and the mystery religions have influenced the later Roman Empire and Christianity?

Effect to the islamic concept of jihad : In what ways were the Crusades similar in nature and effect to the Islamic concept of jihad?

User Account

All Pages